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Some relics will be linked with the Key, and you must choose between the relic and the Key. Last, the Sapphire Key is earned from one of the many relic-containing chests throughout the Spire. There is only one such icon per Act, and once beaten it won't show up in future Acts, so plan your route accordingly. This elite will be one of the ones normally encountered in that Act but will have an extra buff such as extra max HP, extra strength, or health regeneration every turn.
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You can differentiate this enemy from normal elite enemies on the map by the flame effect behind their icon. The Emerald Key is earned by defeating a powered-up elite enemy. Keep in mind this will always be an option until the Key is taken, so wait until there isn't a more important Rest Site option to take, like recovering health or upgrading a crucial card. The keys that have already been collected can be seen in the upper left corner of the screen, and each key is found through a slightly different method: The Ruby Key is earned by choosing the Recall option at a Rest Site. Once you've satisfied this first requirement, you'll be able to earn all three keys on a single run up the Spire in order to unlock Act IV.
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